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Mordecai Lab, Stanford University


Erin Mordecai is an assistant professor in Biology at Stanford University. 

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Mordecai Lab, Stanford University


Erin Mordecai is an assistant professor in Biology at Stanford University. 

erin mordecai

Erin Mordecai is an assistant professor in Biology at Stanford University.

Our research focuses on the ecology of infectious disease. We are interested in how climate, species interactions, and global change drive infectious disease dynamics in humans and natural ecosystems. This research combines mathematical modeling and empirical work.

Smut fungus 

Avena fatua in Pearson-Arastradero Park,
Palo Alto, California.

Rust fungus

Elymus glaucus in Jasper Ridge Biological Preserve, Woodside, California.

Leaf spot

Pisonia grandis leaf on Palmyra Atoll.

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Our Research


Work in the lab uses mathematical models and empirical data to study the ecology of infectious diseases

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Our Research


Work in the lab uses mathematical models and empirical data to study the ecology of infectious diseases

Pathogen impacts on plant communities

Parasitism is one of the most common strategies of life on earth, and natural plant communities host a huge diversity of pathogens. Our work examines feedbacks between pathogen and host communities in California grasslands and other systems. We are growing fungal pathogens of native and exotic grasses in culture to identify the pathogen community in this vast and heavily invaded ecosystem. In tandem, we are experimentally measuring pathogen impacts on plant competition and other demographic rates. Combined with mathematical models, this work will help us understand how pathogens affect the composition of plant communities. We are particularly interested in how generalist pathogens that can be transmitted between host species may indirectly modify competition. In California grasslands, where native and exotic grasses compete intensely and share pathogens, disease may be a major driver of coexistence and competitive exclusion. This work takes place in the amazing and beautiful Jasper Ridge Biological Preserve, just seven miles from Stanford University main campus.

 

Effects of temperature on vector-transmitted diseases

Mosquitoes and other biting insects transmit many of the most important, devastating, and neglected human infectious diseases, including malaria, dengue, chikungunya, and West Nile virus. Because these disease vectors are small-bodied and cold-blooded they are sensitive to environmental temperature. As a result, climate change is likely to shift the global distribution of these vector-borne diseases. We have used laboratory data and a mathematical model to show that thermal responses of traits involved in malaria transmission are nonlinear, and that the resulting optimum temperature for malaria transmission is just 25°C. The model allows us to make nuanced predictions about where climate change may most impact malaria transmission. In a new project funded by the National Science Foundation Ecology and Evolution of Infectious Diseases Program, we are working to predict thermal responses in 13 vector-borne diseases, to map these predicted changes, and to estimate their uncertainty using mathematical models and Bayesian statistics. Our work will also explore local thermal adaptation in two key mosquito species that transmit dengue, chikungunya, and yellow fever: Aedes aegypti and Aedes albopictus. Collaborators include Leah Johnson, Sadie Ryan, Krijn Paaijmans, Samraat Pawar, Kevin Lafferty, Jason Rohr, Van Savage, Matt Thomas, Anna Stewart Ibarra, and others.

 

Maintenance of parasite diversity

Parasites live in diverse communities, competing for host resources. What mechanisms allow all these parasites to coexist? We have studied how several life history tradeoffs may promote parasite coexistence. In California salt marshes, we have shown that a competition – colonization tradeoff promotes coexistence for trematode parasites, but that other mechanisms may also contribute. In grasslands, we have shown that competing viruses coexist by coinfecting host plants and via a tradeoff between transmission efficiency and the ability to use multiple vector species. This work is in collaboration with Alejandra Jaramillo, Kevin Lafferty, Ryan Hechinger, Jake Ashford, Charles Mitchell, and Kevin Gross.






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The Lab


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The Lab